effects of aspirin as an anti-inflammatory drug on azole-resistant candida glabrata in vitro
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چکیده
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منابع مشابه
Effects of Aspirin as an Anti-inflammatory Drug on Azole-resistant Candida glabrata In Vitro
Candida glabrata previously considred as a nonpa-thogenic commensal microorganism of human mucosal tissues, is now mentioned as the second or third cause of nosocomial candidiasis and have significantly increased recently due to immuno-suppressive therapies (1). Among the Candida species, C. glabrata is inherently resistant to azole anti-fungal agents. The mutations occurred in several ergoster...
متن کاملazole-resistant Candida glabrata
Case report-Subjects-Three cases are described oflong-standing vaginal candidosis due to Candida glabrata. These had failed to respond to local and systemic antifungals. In each case the infecting strain appeared resistant to a range of azole drugs in vitro. Clinical course-Case one-This patient recovered following prolonged treatment with oral itraconazole in combination with oral and vaginal ...
متن کاملMolecular biological characterization of an azole-resistant Candida glabrata isolate.
Two isolates of Candida glabrata, one susceptible and one resistant to azole antifungals, were previously shown to differ in quantity and activity of the cytochrome P-450 14alpha-lanosterol demethylase which is the target for azole antifungals. The resistant isolate also had a lower intracellular level of fluconazole, but not of ketoconazole or itraconazole, than the susceptible isolate. In the...
متن کاملMechanisms of azole resistance in petite mutants of Candida glabrata.
We previously showed that resistant colonies of Candida glabrata inside the azole inhibition zones had respiratory deficiency due to mutations in mitochondrial DNA. Here, we analyzed the mechanisms of azole resistance in petite mutants of C. glabrata obtained by exposure to fluconazole or induced by ethidium bromide. The respiratory deficiency of these mutants was confirmed by oxygraphy and flo...
متن کاملContribution of CgPDR1-Regulated Genes in Enhanced Virulence of Azole-Resistant Candida glabrata
In Candida glabrata, the transcription factor CgPdr1 is involved in resistance to azole antifungals via upregulation of ATP binding cassette (ABC)-transporter genes including at least CgCDR1, CgCDR2 and CgSNQ2. A high diversity of GOF (gain-of-function) mutations in CgPDR1 exists for the upregulation of ABC-transporters. These mutations enhance C. glabrata virulence in animal models, thus indic...
متن کاملDrug-Resistant Candida glabrata Infection in Cancer Patients
Cancer patients are at risk for candidemia, and increasing Candida spp. resistance poses an emerging threat. We determined rates of antifungal drug resistance, identified factors associated with resistance, and investigated the correlation between resistance and all-cause mortality rates among cancer patients with ≥1 C. glabrata-positive blood culture at MD Anderson Cancer Center, Houston, Texa...
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عنوان ژورنال:
iranian journal of public healthجلد ۴۵، شماره ۱۱، صفحات ۱۵۲۳-۱۵۲۴
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